The role of Botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury

The mechanism of peripheral axon transport in neuropathic pain is still unclear. Chemokine ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) and GABA transporter 1 (GAT-1) play an important role in the development of pain. The aim of this study was to explore the axonal transport of CXCL13/CXCR5 and GAT-1 with the aid of the analgesic effect of botulinum toxin A (BTX-A) in rats. Chronic constriction injury (CCI) rat models were established. BTX-A was administered to rats through subcutaneous injection. The pain behaviors in CCI rats were measured by paw withdrawal threshold (PWT) and paw withdrawal latencies (PWL). The levels of CXCL13/CXCR5 and GAT-1 were measured by western blots.