Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE30255
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HCC827 cells were grown in gradually increasing concentrations of cetuximab beginning at 0.1 ug/ml. Drug concentrations were slowly increased until the resistant cells were able to proliferate in 100 ug/ml of cetuximab. Individual clones of cetuximab resistant (CR; CR1 to CR4) cells were isolated and confirmed to be drug resistant. Number of samples: 5. Parental HCC827 as a control. 4 Cetuximab resistant clones
创建时间：
2013-08-21
