Association for SNPs Carried Forward to Replication: Discovery/Replication Samples and Meta-Analyses.

NOTE: P values S8 Table. In the Discovery sample gene-based test for RC: NPS was the top ranked gene (p = 1.5x10-5), while VPS13B and DOPEY2 were nominally associated (p = 0.02, 0.04 respectively). In the gene-based test for IQ: DGKB and ABHD4 were nominally associated (p = 0.03, 8.1x10-4 respectively). RBM20 and PRR5L were not VEGAS-listed genes.aSample sizes: Australian Discovery (1. N = 497 (243 families); 2. N = 1999 (894 families), English ALSPAC (N = 4078 unrelated), Scottish LBC1936 (N = 1001 unrelated), Dutch NTR (N = 920 (340 families)), Norwegian NCNG (N = 670 unrelated).bThis set of SNPs are from the top 50 RC SNPs. Results for all replication SNPs are shown in supplementary S9–S10 Tables. Measures examined in meta-analysis: Discovery – RC; ALSPAC/LBC1936/NCNG – Matrix Reasoning; NTR—Raven’s Progressive Matrices.cThis set of SNPs are from the top 50 IQ SNPs. Results for all replication SNPs are shown in supplementary S9–S10 Tables. Measures examined in meta-analysis: Discovery—IQ from the Multidimensional Aptitude Battery (5 subtests), ALSPAC and NCNG – IQ from the WASI (2 subtests—includes Matrix Reasoning), LBC1936—Moray House.dFurther support for this SNP was found in meta-analysis for Working Memory (rs4390263, p = 0.023; rs4482248, p = 0.026; N = 1825; Discovery – PCA-derived Working Memory; LBC1936 – Letter Number Sequence; NCNG – Digit Symbol).Association for SNPs Carried Forward to Replication: Discovery/Replication Samples and Meta-Analyses.