Response of the amnion to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque. Response of the amnion to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque

We demonstrate that during chorioamnionitis the amnion transcriptome is dominated by immune and inflammation related genes, largely driven by the NF-kB pathway. The amnion mesenchymal cells expressing We demonstrated that during chorioamnionitis the amnion transcriptome is dominated by immune and inflammation related genes, largely driven by the NF-kB pathway. CD14 and other myeloid cell markers increase in number with increased expression of innate immune activation markers during intrauterine infections. Overall design: We compared transcriptomics of the amnion in a preterm rhesus macaque model of IUI-induced by lypopolysaccharide with human cohorts of chorioamnionitis.