Effects of phloretin, ritonavir, indinavir and Bay-876 on glucose transport during peritoneal dialysis in Sprague-Dawley rats

We previously found that phloretin, a general blocker of facilitative glucose channels (GLUTs), reduced glucose absorption and improved ultrafiltration during peritoneal dialysis (PD) in rats. It is as yet unknown via which GLUTs such transport occurs and whether transport occurs in a trans-cellular fashion. This study was undertaken to elucidate (i) whether glucose may be transferred in a trans-cellular fashion across peritoneal cells and (ii) via which GLUTs glucose transport may be partly mediated during PD. The main study was performed in thirty-two Sprague-Dawley rats in which PD was performed by instillation of 20 mL 2.3% glucose PD fluid which was allowed to dwell for 60 min. Animals were given an IV infusion of [18F]-deoxyglucose allowing us to monitor glucose transport in both directions: from the dialysate to the circulation and vice versa. Animals received either no treatment (control), or received intra-peritoneal phloretin (50 mg/L), ritonavir (60 mg/L), or BAY-876 (25 mg/L..., , , GENERAL INFORMATION

1. Title of Dataset: Effects of Phloretin, Ritonavir, Indinavir, and BAY-876 on Glucose Transport During Peritoneal Dialysis in Sprague-Dawley Rats
2. Author Information
A. Principal Investigator Contact Information
Name: Carl Öberg
Institution: Lund University, Medical Faculty
Address: Box 117, SE-221 00
Email: [[e-mail]](mailto:[e-mail])
3. Date of data collection June 2022 to September 2023
4. Geographic location of data collection: Lund, Sweden
5. Information about funding sources that supported the collection of the data: Funding by the Crafoord Foundation, Lund University Medical Faculty Foundation grant YF 2020-YF0056, and The Inga-Britt and Arne Lundberg’s Research Foundation (all to C.M. Öberg).

### DATA & FILE OVERVIEW

1. File List: fdgdata.xls, indinavir.xls

**DATA-SPECIFIC INFORMATION FOR: fdgdata.xls**

1. Number of variables: 130
2. Number of cases/rows: 32
3. Variable List:

animal, \"unique number assigned...