Inhibitory binding constants (Ki, nM) for CRF ligands bound to CRFRs expressed in E.coli membranes as measured by competitive displacement of bound labeled astressin.

Ki values determined by analysis using competitive displacement of labeled astressin as described in Materials and Methods. r: rat; m: mouse; h: human. N.D.: No displacement.*Inhibitory binding constants (Ki, nM) for PD-sauvagine bound to CRFRs expressed in E. coli membranes were measured by competitive displacement of bound labeled PD-sauvagine.