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Food protein-induced activation and death of CD4+ Helios+ Foxp3- T cells is required for IL-10 production and intestinal homeostasis

ChEBI2016-07-01 更新2026-07-12 收录

肠道免疫耐受

食物蛋白免疫反应

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-66938 数据链接链接失效反馈

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Food protein-induced activation and death of CD4+ Helios+ Foxp3- T cells is required for IL-10 production and intestinal homeostasis

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创建时间：

2016-07-01

肠道免疫耐受

单细胞RNA测序

Commensal immune tolerance requires cells that actively sense and suppress inflammation. To understand how commensal tolerance works, mice colonized with recombinant Candida albicans expressing model

NIAID Data Ecosystem70

A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life. A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life

调节性T细胞

肠道免疫耐受

Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, pla

NIAID Data Ecosystem70

Neonatally imprinted mesenteric lymph node stromal cell subsets induce tolerogenic dendritic cells [Tx FSC]. Neonatally imprinted mesenteric lymph node stromal cell subsets induce tolerogenic dendritic cells [Tx FSC]

肠道免疫耐受

淋巴结转移研究

Gut-draining mesenteric lymph nodes (mLNs) play a key role in peripheral tolerance towards food and commensal antigens by providing an optimal microenvironment for efficient de novo induction of Foxp3

NIAID Data Ecosystem60

Comparison of splenic and small intestine lamina propria macrophages

肠道免疫耐受

巨噬细胞功能

The intestinal immune system must elicit robust immunity against harmful pathogens but restrain immune responses directed against commensal microbes and dietary antigens. The mechanisms that maintain

NIAID Data Ecosystem70

ROR?t? Dendritic Cells Are a Distinct Lymphoid-Derived Lineage

细胞谱系分化

肠道免疫耐受

How tolerogenic dendritic cell (DC) lineages are established to prevent inappropriate immune responses to commensals and food antigens remains unclear. We identify ROR?t? DCs in mice as a distinct lym

NIAID Data Ecosystem60

Food protein-induced activation and death of CD4+ Helios+ Foxp3- T cells is required for IL-10 production and intestinal homeostasis

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