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Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and their denucleation

ChEBI2011-01-01 更新2026-07-21 收录

晶状体发育

细胞终末分化机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-25169 数据链接链接失效反馈

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Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and their denucleation

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创建时间：

2011-01-01

RNA结合蛋白

晶状体发育

Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a

NIAID Data Ecosystem80

MOESM1 of Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways

染色质可及性分析

晶状体发育

Additional file 1: Table S1. Summary for the ATAC-seq data.

NIAID Data Ecosystem70

Schematic representation of the consequences of ectopic Wnt/β-catenin signaling activation, or β-catenin stabilization in a specific lens region from E12.0.

晶状体发育

Wnt信号通路调控

(A) αA-CLEF (B) MLR39; Catnblox(Ex3) [27] (C) MLR10; Catnblox(Ex3) [27]. Picture of eye illustrates stage E12.0. Blue color represents the part of the lens where the activity of Wnt/β-catenin signalin

NIAID Data Ecosystem40

miR-204 Targeting of Ankrd13A Controls Both Mesenchymal Neural Crest and Lens Cell Migration

细胞迁移调控

晶状体发育

Loss of cell adhesion and enhancement of cell motility contribute to epithelial-to-mesenchymal transition during development. These processes are related to a) rearrangement of cell-cell and cell-subs

NIAID Data Ecosystem70

Gene regulation by Pax6 in the lens placode - E9.5 (2). Mus musculus

晶状体发育

Pax6基因功能

Wild type or Pax6 fx/fx; Le-Cre-positive (Pax6-/-) surface ectoderm from E9.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified, pooled for each genotyp

NIAID Data Ecosystem50

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and their denucleation

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