Kaempferol Improves Exercise Performance and Its Potential Mechanism

Kaempferol is a natural flavonoid with reported bioactivities, however its effects on exercise performance and muscle metabolism are unclear. This study investigated kaempferol for improving exercise performance and potential underlying mechanism in vivo and in vitro. In vitro, kaempferol promoted glucose uptake, protein synthesis and mitochondrial function along with decreasing oxidative stress in C2C12 myotubes. Moreover, the PI3K-AKT and MAPK signaling pathways were proved be activated with kaempferol by transcriptomic analysis. To investigate the molecular mechanisms of kaempferol influence on muscle function, C2C12 myotubes were exposed to 25 μM kaempferol for 24 hours. Analysis unveiled differential gene expression between the treated and untreated groups.