Expression data from NSCLC cells before and after berberine treatment

Natural products play an important role in the prevention and treatment of lung cancer. Gene chip technology to analyze the differentially expressed genes in adenocarcinoma after berberine treatment We found that cell cycle and DNA replication pathway were significantly enriched in patients with lung adenocarcinoma compared with normal tissues. After berberine treatment, the expression of FoxM1 closely related to survival and survival related genes in cell cycle and DNA replication pathway were significantly down regulated. Berberine could inhibit the survival of lung adenocarcinoma xenografts and down regulate the expression of FoxM1 in vivo. Berberine interfered with the expression of survival related gene POLE2 in DNA replication through FoxM1.