Full gene rankings based on the estimated area under the coefficient function curve (analysis on the full data set).

Gene rankings of all selected genes based on the magnitude of the genetic effect on drug response. A positive (+) sign translates to a positive effect on cells survival after drug administration, a negative (-) sign translates to a negative effect on cells survival and a mixed (0) effect translates to a varying effect on cells survival which depends on drug dosage. Spearman’s correlation is calculated between drug dosage and gene estimated coefficient function values as an indicator of the magnitude change of the gene effect over the increasing dosage. Area corresponds to the area under the estimated coefficient curve and the SD corresponds to the standard deviation of the area based on bootstrapping. Mean fold change is calculated between the selected gene expression values of the cell lines carrying BRAF mutations with respect to wild type. Protein-protein interaction network distance is computed based on the shortest interaction path between the BRAF gene and each of the selected genes. Here, NI denotes absence of any interaction. (XLSX)