PRKAA2 phosphorylates PLINs

Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (PLIN) proteins and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Subsequently, AMPK binds and phosphorylates perilipins targeting them for lipophagy (S Kaushik et al. 2015, S Kaushik et al. 2016). The precise phosphorylation site(s) on PLINs are unknown. Experiments confirming this finding were performed in mouse models.

脂溶吞噬是一种自噬降解脂滴为脂肪酸的过程。脂滴被脂滴素蛋白（Perilipin，简称PLIN）所包裹，这些蛋白必须被清除以降解脂滴内部的脂质。细胞质热休克同源蛋白71 kDa（HSPA8）与脂滴表面的PLIN2和PLIN3结合。随后，AMPK结合并磷酸化脂滴素蛋白，将其靶向至脂溶吞噬（S Kaushik 等人，2015，S Kaushik 等人，2016）。PLINs上的精确磷酸化位点尚不明确。该发现的实验验证是在小鼠模型中进行的。