Crystal structure of Pol theta polymerase domain in complex with compound 22
收藏Protein Data Bank Japan2024-01-31 更新2026-04-19 收录
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Crystal structure of Pol theta polymerase domain in complex with compound 22 Descriptor: (2~{S},3~{R})-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-~{N}-methyl-~{N}-(3-methylphenyl)-3-oxidanyl-pyrrolidine-2-carboxamide, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... Authors: Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. Deposit date: 2022-05-19 Release date: 2022-10-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.829 Å) Cite: Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
创建时间：
2022-05-19
