Geniposide suppressed tumor progression through DUOX1-mediated ferroptosis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) poses a formidable challenge within the spectrum of digestive system cancers due to its poor prognosis. Geniposide, an iridoid glucoside extracted from the fruits of Gardenia jasminoides Ellis, exhibits a diverse array of biological activities. The objective of this study is to delineate the specific roles and underlying mechanisms of geniposide on the progression of HCC. Overall design: Huh7 and HepG2 cells were subjected to treatment with or without geniposide for 48 h, after which they were collected for transcriptome sequencing