Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"

This record contains raw data related to article “ Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"

Up to 40% of patients with inflammatory bowel disease (IBD) present disturbed psychosocial functioning. We previously identified a gut vascular barrier (GVB) which controls the dissemination of bacteria from the intestine to the liver. Here we describe a vascular barrier in the brain choroid plexus (CP) (PVB) which is modulated in response to intestinal inflammation via bacteria-derived lipopolysaccharide (LPS). The inflammatory response induces PVB closure consequently to GVB opening, through the upregulation of the Wnt/b catenin signaling pathway rendering it inaccessible to large molecules. Genetically-driven closure of CP endothelial cells elicits a deficit in short-term memory and anxiety-like behavior, suggesting that PVB closure correlates with mental deficits. IBD-related mental symptoms may thus be the consequence of a deregulated gut-brain vascular axis.