Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16
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Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16 Descriptor: 12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one, Mitogen-activated protein kinase kinase kinase 9, SULFATE ION Authors: Fedorov, A.A, Fedorov, E.V, Meyer, S.L, Hudkins, R.L, Almo, S.C. Deposit date: 2008-07-14 Release date: 2009-03-31 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models. J.Med.Chem., 51, 2008
创建时间：
2008-07-14
