5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol

Diphosphoinositol polyphosphate phosphohydrolases (DIPP), also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11).<br><br>The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).

二磷酰肌醇多磷酸磷酸水解酶（Diphosphoinositol polyphosphate phosphohydrolases，简称DIPP），亦称为核苷二磷酸连接基团X结构域（nucleoside diphosphate-linked moiety X motif，简称NUDT）蛋白，其功能为将肌醇5-二磷酸-1,2,3,4,6-五磷酸（inositol 5-diphospho-1,2,3,4,6-pentakisphosphate，简称5-PP-IP5）去磷酸化，转化为肌醇1,2,3,4,5,6-六磷酸（inositol 1,2,3,4,5,6-hexakisphosphate，简称IP6）。参与此过程的NUDT蛋白包括：核苷二磷酸连接基团X结构域3（nucleoside diphosphate-linked moiety X motif 3，简称NUDT3）、4（NUDT4）、10（NUDT10）和11（NUDT11）。以下列出上述蛋白及其相应的文献引用：NUDT3（Safrany et al. 1999，Safrany et al. 1998，Yang et al. 1999，Caffrey et al. 2000），NUDT4（Caffrey et al. 2000），NUDT10（Leslie et al. 2002，Hidaka et al. 2002）和NUDT11（Leslie et al. 2002，Hidaka et al. 2002）。