Electroacupuncture Suppresses Premature Ventricular Complexes Occurring Post-myocardial Infarction through corticothalamic circuit

Electroacupuncture (EA) has been shown to suppress premature ventricular complexes (PVCs) following myocardial infarction (MI) in humans. However, the specific neural circuitry and causal mechanisms underlying this effect remain unclear. Here, we reveal a previously unrecognized connection from the primary motor cortex (M1) to the nucleus rostral ventrolateral medulla (RVLM) circuitry via the layer 5 of the primary motor cortex (M1L5)-zona incerta (ZI) pathway, which selectively suppresses PVCs in post-MI mice. Utilizing viral tracing, fiber photometry recordings, and optogenetic stimulation, we demonstrate that EA inhibits glutamatergic projections from M1L5 to ZI, leading to the activation of local GABAergic neurons and subsequent inhibition of RVLM (M1L5-ZI-RVLM). Furthermore, optogenetic or chemogenetic inhibition of the M1L5-ZI-RVLM circuit replicates the anti-PVC effects observed with EA in MI mice. Artificial activation of M1L5-projecting ZI neurons reverses the suppressive effects of EA on PVCs in MI mice. Overall, our findings highlight the M1L5-ZI-RVLM circuit as a crucial mediator of EA-induced suppression of PVCs following myocardial infarction. Additionally, this newly identified corticothalamic circuit may represent a promising target for mitigating PVCs post-myocardial infarction.

搜集汇总

背景与挑战

背景概述

该数据集提供了一项关于电针抑制心肌梗死后室性早搏的神经机制研究数据。研究揭示了一个关键的皮质-丘脑回路（M1L5-ZI-RVLM），该回路介导电针的治疗效果，并通过病毒追踪、光遗传学等方法验证了其因果作用。数据集包含支持研究结果的图表原始数据，以Excel文件形式存储，用于进一步分析或验证。