High-fiber Mango By-Products-Based Confectionery Modulates Fecal Microbiota and Decreases Liver Fat Accumulation in Wistar Rats Fed a High-fat Diet

Unhealthy Westernized diets alter gut microbiota composition and diversity, significantly impacting host health and exacerbating issues like childhood obesity. Conversely, diets rich in fiber and antioxidants, commonly found in fruits, promote beneficial gut microorganisms and increase short-chain fatty acid (SCFA) production, influencing lipid metabolism. This study investigates a high-fiber mango by-product confectionery (MC) tailored for children, using Wistar rats as models. Results demonstrate that MC supplementation decreases gut microbiota obesogenic specie (e.g., Coprococcus catus, Ruminococcus gnavus, Ruminoccocus torques, [Clostridium] hylemonae, Coprococcus comes, and Blautia sp. LZLJ-3), and protects against diversity loss. SCFA production correlates with fiber intake, implying a role in lipid metabolism regulation, suggesting MC is a mitigating liver fat accumulation and adipocyte hypertrophy. These findings underscore the potential of the high-fiber mango by-product confectionery in mitigating obesity biomarkers. However, further research is necessary to fully comprehend the metabolic effects of MC supplementation.