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HIGHLY DIVERSE TCRalpha CHAIN REPERTOIRE OF PRE-IMMUNE CD8+ T CELLS REVEALS NEW INSIGHTS IN GENE RECOMBINATION

ChEBI2012-02-09 更新2026-07-21 收录

T细胞受体谱系

基因重组机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-35626 数据链接链接失效反馈

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HIGHLY DIVERSE TCRalpha CHAIN REPERTOIRE OF PRE-IMMUNE CD8+ T CELLS REVEALS NEW INSIGHTS IN GENE RECOMBINATION

应用场景：

创建时间：

2012-02-09

DNA甲基化

基因重组机制

We report the existence of both methylcytosine and hydroxymethylcytosine in the genomic DNA of the ciliate Oxytricha trifallax during its genome rearrangement process. These modifications are dynamica

NIAID Data Ecosystem80

ROR𝛾t directs upregulation of RAG gene expression in DP thymocytes and serves as a multi-faceted regulator of the Tcra repertoire.. ROR𝛾t directs upregulation of RAG gene expression in DP thymocytes and serves as a multi-faceted regulator of the Tcra repertoire.

T细胞发育

T细胞受体谱系

Naik et al. show that RAG gene upregulation in DP Thymocytes is controlled by DPASE, a DP-specific open chromatin region in RAG locus. Reduced RAG expression in DPASE KO mice result delayed and incomp

NIAID Data Ecosystem70

Transmission into NCOs at additional SNPs at hotspots F and K shows no conversion bias.

基因重组机制

非交换重组分析

1i.e. excluding any NCO event that involves markers F6.1 or K7.4, including co-conversion events.

Figshare2015-12-02 更新50

NGS data of T-cell receptor repertoire of naive CD4 and CD8 T-cells in healthy donors

T细胞受体谱系

免疫组库分析

sequence data of 18 healthy donors (TCRbeta repertoire) and 5 healthy donors (TCRalpha repertoire. See Klarenbeek et al. PLOS ONE 2015 (accepted):Somatic variation of T-cell receptor genes strongly as

NIAID Data Ecosystem80

TCR repertoire of ankylosing spondylitis patients

T细胞受体谱系

强直性脊柱炎机制

This study was aimed to search for AS-specific T cell receptor (TCR) variants, to determine the phenotype and involvement of corresponding T-cells in joint inflammation.

NIAID Data Ecosystem60

HIGHLY DIVERSE TCRalpha CHAIN REPERTOIRE OF PRE-IMMUNE CD8+ T CELLS REVEALS NEW INSIGHTS IN GENE RECOMBINATION

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