In this dataset, we applied high-throughput nanowell single cell DNA-ATAC co-assay sequencing to profile copy number alterations and chromatin accessibility in 31,176 epithelial cells isolated from br

NIAID Data Ecosystem10

Single cell multiomics guided mechanistic understanding of Fontan-associated liver disease

单细胞多组学

先天性心脏病继发肝病

Liver biopsy samples were from patients with Fontan circulation (FC) and healthy patients undergoing resection or transplant for hepatoblastoma. We used snRNA-ATAC-seq to generate the transcriptomic

NIAID Data Ecosystem00

Integrated genome and transcriptome sequencing from the same cell. Integrated genome and transcriptome sequencing from the same cell

单细胞多组学

甲基化与转录组关联分析

Single-cell genomics and single-cell transcriptomics have recently emerged as powerful tools to study the biology of single cells at a genome-wide scale. Here we describe a method that allows the inte

NIAID Data Ecosystem20

Single-cell multiomic profiling of lung immune cells identifies novel asthma risk genes and cell-type specific functions

哮喘遗传机制

单细胞多组学

Genetic variants associated with asthma are mostly in non-coding regions, so it is challenging to identify their target genes and the cellular contexts. Functional profiling of blood immune cell types

NIAID Data Ecosystem00

Decoding Aging in the Heart via Single Cell Dual Omics of Non-Cardiomyocytes

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