Multi-omics profiling of distinct type I interferon responses in human glioblastoma and osteosarcoma cell lines

A potential new line of anticancer therapy is the use of oncolytic viruses. However, there is a heterogenicity among various types of tumors in response to such treatment. This study is aimed at identifying molecular mechanisms that confer sensitivity to viral infection. We investigated type I interferon responses in human glioblastoma cell line DBTRG-05MG (resistant to viral infection) and osteosarcoma cell line HOS (sensitive to viral infection). We applied a multi-omics approach with included transcriptome, proteome and editome analysis of these cell lines before and after interferon treatment. Transcriptomic profiles of DBTRG-05MG and HOS cell lines before and after interferon type I treatment.