Antibiotic support of subgingival therapy affects the oral microbiome of periodontitis patients positively and remarkably, but only temporarily

V4 region of 16S rDNA from samples taken from periodontal pockets of patients with severe (formerly aggressive) periodontitis. Patients were randomly divided into two treatment groups differing in use of systemic antibiotics. The samples were taken 4 times - before treatment, immediately after treatment (2 weeks after SRP), after additional 3 months, and finally after 18 months.