Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene

Data are expressed as means ± standard deviation (SD) and each experiment was repeated at least 3 times. Statistical analyses were performed using Student’s t-test for comparisons between two groups and two-way ANOVA followed by Tukey’s multiple comparisons test for analyses involving two independent variables (performed using GraphPad Prism version 8.0.1). The normality and homogeneity of variances were verified before applying parametric tests. Differences were considered statistically significant at p < 0.05, with significance levels indicated as follows: p < 0.05, p < 0.01, p < 0.001, and p < 0.0001. RT-qPCR and Western Blot Fig 3B, S1, and the commercial CellTiter Glo Luminescent Cell Viability Assay kit (Promega) for Fig4B and S2