Bulk RNA-seq profiling of cancer-associated fibroblast co-culture systems reveals subtype-specific transcriptional programs

This project includes bulk RNA sequencing data generated from tumor organoid co-culture systems incorporating cancer-associated fibroblasts (CAFs) and immune cell populations. The study aims to characterize the transcriptional responses induced by stromal and immune interactions, dissect subtype-specific CAF signaling, and reveal how fibroblast-immune-tumor crosstalk shapes the tumor microenvironment across cancer models.