The Structure of PRMT4 in complex with SGC8172
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The Structure of PRMT4 in complex with SGC8172 Descriptor: 5'-S-(3-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}propyl)-5'-thioadenosine, Histone-arginine methyltransferase CARM1 Authors: Bush, M, Noinaj, N, Huang, R, Deng, Y. Deposit date: 2025-04-13 Release date: 2026-05-13 Last modified: 2026-05-27 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Tailoring PRMT Inhibition: Shifting PRMT7 Selectivity to PRMT4 through "T-Shape" Strategy and "Linker-Specific" Preferences. J.Med.Chem., 69, 2026
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2025-04-13
