Alpha-Synuclein Induces the Unfolded Protein Response in Parkinson's Disease SNCA Triplication iPSC-Derived Neurons

The alpha Synuclein (SNCA) gene is one of the most commonly implicated mediator of Parkinson Disease (PD), changes in dosages are directly associated severity of PD. Here we aim to compare expression within induced pluripotent stem cells derived from a patient with a triplication of the SNCA locus to an isogenic IPSC line with normalized gene dosage through CRISPR/Cas9 mutagenesis.