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Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide

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Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
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Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide Descriptor: 3-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin Authors: Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W. Deposit date: 2012-06-08 Release date: 2013-02-20 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate. J.Am.Chem.Soc., 135, 2013
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2012-06-08
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