five

Synthesis of the Putative Structure of Tridachiahydropyrone

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Synthesis_of_the_Putative_Structure_of_Tridachiahydropyrone/3291451
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A short total synthesis of the putative structure of the marine natural product tridachiahydropyrone as a single enantiomer is described. Novel steps include a cuprate addition and cyclization to form a cyclohexanone ring and formation of the bicyclic pyrone with P2O5 on Celite. The spectroscopic data obtained for compound 1 do not match those reported for tridachiahydropyrone; therefore, revision of the assigned natural product structure is warranted.
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2016-05-06
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