Data Base: Data included: individual methylation values per CpG site, clinical and sociodemographic variables

This dataset supports the study "Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos", published in Frontiers in Aging Neuroscience. The case-control study included 108 patients with Parkinson’s disease (PD) and 108 matched controls of Mexican Mestizo ancestry. DNA methylation levels at specific CpG sites within the promoter region of MAPT and intron 1 of SNCA were measured using bisulfite pyrosequencing.
Significant global and site-specific hypomethylation was found in PD patients compared to controls. Stratified analyses revealed region-specific (northern and central Mexico) and sex-specific methylation differences: MAPT hypomethylation was prominent in men, while SNCA hypomethylation was significant in women. Logistic regression confirmed the association of MAPT and SNCA methylation with PD risk, suggesting these epigenetic changes may serve as peripheral biomarkers in a population-specific context.