Gene expression profile at single nuclei level of cerebellar neurons (Purkinje cells) and glia (Bergmann glia, velate astrocytes and oligodendrocytes) in a transenic mouse model of Spinocerebellar Ataxia Type 1 (SCA1)

Cerebellar glia are affected in SCA1. We used single nuclei RNA sequencing (snRNA-seq) to analyze the gene expression changes in glia in response to neuronal dysfunction in SCA1. Cerebellar nuclei were isolated from 12 weeks old SCA1 mice and Wild type (WT) sex matched littermate controls and analyzed using snRNAseq.