Asymmetric Multicomponent [C+NC+CC] Synthesis of Highly Functionalized Pyrrolidines Catalyzed by Silver(I)

Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective AgI-catalyzed asymmetric [C+NC+CC]
coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing
stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines
for both target- and diversity-oriented syntheses.