Investigating the expression signatures of circRNA in pulmonary arteial hypertension

To investigate the underlying mechanism of pulmonary hypertension, the model of hypoxia-treated pulmonary arterial hypertension (PAH) rats were constructed to detect the differentially expressed profile of circRNAs in lung tissue of PAH rat. The whole genome microarray expression profiling analysis as a discovery platform have been employed to identify genes difference.为探究肺动脉高压（pulmonary hypertension）的潜在发病机制，本研究构建了经缺氧处理的动脉性肺动脉高压（PAH）大鼠模型，以检测PAH大鼠肺组织中环状RNA（circRNAs）的差异表达谱。本研究采用全基因组微阵列表达谱分析作为发现平台，用于鉴定差异表达基因。