Effects of TCDCA-FXR on obesity-induced endothelial dysfunction and hypertension

Regarding the role of TCDCA in alleviating obesity-induced ED, we sought to identify the key targets that could directly clarify the biological effects of TCDCA. We carried out RNA-seq of human umbilical vein endothelial cells (HUVECs) treated with vehicle or TCDCA.To further explore the role of TCDCA and identify its endothelial receptor, we performed RNA-seq on HUVECs treated with vehicle or GW4064 Overall design: To investigate the role of TCDCA-FXR in endothelial cells, we performed RNA-seq in TCDCA- and GW4064-treated HUVECs.