Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action
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https://figshare.com/articles/dataset/Total_Synthesis_of_Laspartomycin_C_and_Characterization_of_Its_Antibacterial_Mechanism_of_Action/3123853
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资源简介：
Laspartomycin
C is a lipopeptide antibiotic with activity against
a range of Gram-positive bacteria including drug-resistant pathogens.
We report the first total synthesis of laspartomycin C as well as
a series of structural variants. Laspartomycin C was found to specifically
bind undecaprenyl phosphate (C55-P) and inhibit formation
of the bacterial cell wall precursor lipid II. While several clinically
used antibiotics target the lipid II pathway, there are no approved
drugs that act on its C55-P precursor.
创建时间：
2016-04-14
