BIOGRID CURATED DATA FOR DBF2 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for DBF2 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication

蛋白质-蛋白质、遗传和化学相互作用数据集，针对酿酒酵母（S288c）的DBF2基因，由BioGRID（https://thebiogrid.org）精心编纂；定义：丝氨酸/苏氨酸激酶，参与转录和应激反应；作为从有丝分裂退出过程中基因网络的一部分发挥作用；定位受细胞周期调控；在有丝分裂退出过程中由Cdc15p激活；同时也在调控SWI5和CLB2 mRNA的稳定性方面发挥重要作用；通过磷酸化Chs2p调控初级细胞壁的形成和Hof1p调控细胞分裂；DBF2拥有一个同源蛋白DBF20，该同源蛋白源自全基因组复制。