Association of SNP combinations with abnormal TVU results.

Per allele odds ratios obtained with an additive model restricted to the Caucasian population for the association of combinations of 9p22 SNPs with abnormal screening results are shown. First, combinations of the four most strongly associated SNPs were analyzed. Three groups were created based on the number of minor alleles: 0–2 alleles present, 3–5 alleles present, 6–8 alleles present. Next, the two least correlated SNPs were combined. For the two-SNP combination, homozygote major alleles were considered low risk, while heterozygous alleles and homozygous minor allele genotypes were considered high risk. Three groups were created as follows: low risk by both SNPs, high risk by either one of the SNPs, and high risk by both SNPs.