Greater prenatal PAH exposure was associated with greater body weight in male and female F1 offspring.

Weights of prenatal PAH and control mice were monitored from PND21 day until PND60. Body weight of PAH and control offspring differed significantly by two way ANOVA (GROUP*LITTER SIZE) on PND 25–27 and PND 52–60 for females and PND 30–60 for males. These included differences among females on PND25 (10.84±0.17 g, n = 19 following PAH vs. 8.87±0.90 g, n = 28 following control exposure), PND27 (10.84±0.17 g, n = 19 following PAH vs. 9.79±0.37 g, n = 28 following control exposure), PND52 (19.36±1.69 g, n = 32 following PAH vs. 17.29±1.79 g, n = 41 following control exposure), and PND 60 (22.79±1.92 g, n = 32 following PAH vs. 19.55±2.05 g, n = 41 following control exposure, p<0.05 for each). Examples of differences among males were found on PND30 (12.24±0.26 g, n = 28 following PAH vs. 11.64±0.35 g, n = 35 following control exposure) and PND60 (23.43±1.85 g, n = 28 in PAH vs 20.38±1.60 g, n = 35 following control exposure, p<0.05 for each). Means ± SD are plotted. *refers to p<0.05 determined at each time point.