Histone post-translational modifications of Leishmania braziliensis

Eukaryotic cells have natural resources to maintain their biological activities for the organism. Epigenetics is one of these mechanisms, which plays a fundamental role in the regulation of gene expression, cell cycle progression, DNA repair, etc. Epigenetic control of gene expression occurs when chemical groups are added to some histone amino acids, resulting in dynamic changes in the structure and organization of chromatin, besides being recruiters of protein complexes. Recently, our group described the global map of post-translational modifications of histone (hPTMs) of Trypanosoma cruzi, showing that, despite being unicellular eukaryotes with a characteristic post-transcriptional gene expression, their chromatin is complex with an abundant and variable number of hPTMs. In this work, we describe, the first comprehensive and high-confidence global map, of the hPTMs of Leishmania braziliensis, the etiologic agent of leishmaniasis, distributed in all canonical and some variants.