Top 40 methylation loci with statistically significant methylation-expression correlations using the discretization approach.

Additionally, loci in common with the Pearson correlation method are shown in parentheses.*(−) indicates a negative methylation-expression correlation, where high methylation correlates to lower expression or vice versa. (+) indicates a positive correlation where high methylation correlates to increased expression or vice versa.†P values were obtained after 10,000 random permutations of each class label.‡Gene was selected for further validation.§The methylation level of the probe FRZB_P406_F has a positive correlation with gene expression by both Pearson correlation and the discretization method, while the other probe FRZB_E186_R has a negative methylation-expression correlation by both methods. Only the FRZB_P406_F probe is shown for the discretization method due to its statistical significance.