Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE25911
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资源简介：
MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone marrow cells. MLL-AF9 murine leukemia cells carrying two conditional Dot1l alleles were retrovirally transduced with Cre or empty control vector, and gene expression changes were monitored on day 3, 5, and 7 after transduction.
创建时间：
2019-02-11
