Phenotypes of <i>C155-Gal4/UAS-Aβ</i> and <i>C155-Gal4/UAS-tau</i> Alzheimer Disease Models of <i>Drosophila</i> treated and untreated with 0.001% (w/w) of curcumin.
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aDefined as total number of beam brakes for 16 flies in the DAM2 system over 24 h. Flies were reared at 29°C and assayed at the same temperature. bProtein deposition load determined by visual inspection with a fluorescence microscope of immunofluorescence of antibody detection, of histological sections of Drosophila heads at day 10 for C155-Gal4/UAS-Aβ1–40, C155-Gal4/UAS-Aβ1–42, C155-Gal4/UAS-Aβ1–42;UAS-Aβ1–42, C155-Gal4/UAS-tau; and day 5 for C155-Gal4/UAS-Aβ1–42 E22G. At least 20 fly heads were assayed for each genotype. +++, extensive; ++, intermediate; + detectable; −, not detected; n.a., not assayed. cAggregate deposition load determined by visual inspection with a fluorescence microscope of p-FTAA and immunofluorescence of histological sections of Drosophila heads at day 10 for C155-Gal4/UAS-Aβ1–40, C155-Gal4/UAS-Aβ1–42, C155-Gal4/UAS-Aβ1–42;UAS-Aβ1–42, C155-Gal4/UAS-tau; and day 5 for C155-Gal4/UAS-Aβ1–42 E22G. At least 20 fly heads were assayed for each genotype. +++, extensive; ++, intermediate; + detectable; −, not detected; n.a., not assayed. dNot all flies showed protein aggregates, given is the load when protein aggregates were detected.
