Changes in gut microbiota metatranscriptome induced by a Bifidobacterium lactis CNCM I-2494 fermented milk are associated with improved gastrointestinal comfort. Flatback

Healthy plant-based diets rich in fermentable residues may induce gas-related symptoms, possibly mediated by the gut microbiota. We previously showed that consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. Lactis CNCM I-2494 and lactic acid bacteria improved gastrointestinal comfort in response to a flatulogenic dietary challenge in healthy subjects [PMID: 31991794]. To study the potential effects of the FMP on gut microbiota activity from those subjects, we conducted a metatranscriptomic analysis of fecal samples (n=262), which were collected during the ingestion of a habitual diet and two series of a 3-day high-residue challenge diet, before and following 28-days of FMP consumption. (ClinicalTrials.gov Identifier: NCT01291446)