Replication of rRVF mutant viruses in Aedes aegypti mosquitoes.

1Number of mosquitoes containing detectable virus by plaque assay divided by number of mosquitoes exposed to infectious bloodmeal.2De = number of mosquitoes with RVFV antigen in head tissues divided by number of mosquitoes exposed to infectious bloodmeal.3Di = number of mosquitoes with RVFV antigen in head tissues divided by number of infected mosquitoes.4Te = number of mosquitoes with positive saliva by plaque assay divided by number of mosquitoes exposed to infectious bloodmeal.5Td = number of mosquitoes with positive saliva by plaque assay divided by number of mosquitoes with disseminated infection.6Titer expressed as log10 PFU/mL.7n = 3, titer expressed as log10 PFU/ml; avg is log10 geometric mean; sd is standard deviation.8nd = not done.*value differs significantly from rRVF-wt values; see Table S2 for statistical analysis results.