Treponema pallidum subsp. pallidum strain:UZ1974 Genome sequencing

Treponema pallidum subsp. pallidum (TPA) is the infectious agent of syphilis. Since TPA is uncultivable bacterium, most of the information on TPA genetics comes from genome sequencing and molecular typing studies. This study presents the first complete TPA genome (without sequencing gaps) of isolate that was obtained directly from the clinical material, without multiplication in rabbits (strainUZ1974). The whole genome sequencing was performed by a newly developed Anti-Treponemal Antibody Enrichment (ATAE) technique combined with previously reported Pooled Segment Genome Sequencing (PSGS).