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Granularity of the traditional TAS annotations.

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Figshare2019-04-25 更新2026-04-29 收录
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Example of M.tuberculosis H37Rv with some so-called VapB.VapC TA pairs. We propose a more objective nomenclature of the TAS based on the HMM profiles clusters. Note that all VapCs shown here have a PIN Pfam annotation, however their TASMANIA.Tn (Tn) is split into multiple sub-clusters emphasizing the diversity of the PIN domains. In contrast, their associated so-called VapB-like antitoxins have very diverse Pfam annotations, but consistent TASMANIA.An (An) clusters.
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2019-04-25
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