Dysregulated miRNA targeting in insulin/PI3K-AKT signaling

This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.

本路径图参照Kwon等人所著文献中的图4b构建。在Cmah-null小鼠（经高脂饮食喂养后，易发空腹高血糖、葡萄糖耐受性下降及2型糖尿病特征的鼠类）中，特定miRNA的表达出现失调，进而引发并发症。失调的miRNA通过干预胰岛素信号传导及PI3K/AKT信号通路，影响其靶基因的表达。