A randomised Phase II trial to evaluate the toxicity of high-dose rifampicin to treat pulmonary tuberculosis (Rifatox)

A daily dose of 20 mg/kg RMP for 4 months appears to be safe and well-tolerated.
Although the treatment groups are relatively small, these encouraging results suggest that a daily dose of 20 mg/kg RMP for 4 months is safe enough to be taken forward to larger Phase III trials.

每日摄入20毫克/千克RMP（瑞马匹）的剂量，持续4个月，显示出安全性高且耐受性良好。尽管治疗组的样本量相对较小，但这些令人鼓舞的结果表明，每日摄入20毫克/千克RMP的剂量在持续4个月的情况下，安全性足以推进至更大规模的III期临床试验。