Regulation of transcription by MLL2 complex and MLL complexes-associated protein AKAP95

ChEBI2013-07-01 更新2026-07-21 收录

表观遗传调控

转录调控机制

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Regulation of transcription by MLL2 complex and MLL complexes-associated protein AKAP95

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2013-07-01

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

组蛋白修饰与肿瘤发生

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In this study, our results support a functional divergence between H3K36me2 and H3K36me3 and their non-redundant roles in H3K36M-driven oncogenesis Overall design: 17 ChIP-seq samples, 3 RNA-seq sampl

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DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

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甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

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Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [RNA-seq]

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BACKGROUND/ AIMS: Severe forms of alcoholic liver disease are associated with increased susceptibility to infections largely due to immune dysfunction. In this study, we analyze the phenotypic, molecu

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Transcriptional Dynamics of Skeletal Muscle in Obesity (PRJCA023478)

肥胖相关转录组学

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Skeletal muscle is a metabolically active organ, but it remains largely unexplored in obesity. Here, we used diet-induced mice as obesity model to investigate the effect of obesity on muscle transcrip

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Regulation of transcription by MLL2 complex and MLL complexes-associated protein AKAP95

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