Malvidin ameliorated the murine colitis induced by Citrobacter rodentium

Enteropathogenic E. coli (EPEC) is a causal agent for diarrheal disease and contribute to the burden of mortality for the children under five years old. Although antibiotics are still a major treatment option for EPEC, searching for novel alternatives to antibiotics have been one of the key research areas due to the rapid emergence and spread of antibiotic resistance strains. In this study, we investigated if the anthocyanin malvidin 3-glucoside (MG) can be used to alleviate EPEC-associated phenotypes using a Citrobacter rodentium induced mouse model using a multi-omics approach. MG supplementation restored the bodyweight loss in C. rodentium infected mice and improved the colon crypt length and histopathological scores.

肠致病性大肠杆菌（EPEC）是导致腹泻疾病的病原体，并加剧了五岁以下儿童死亡率负担。尽管抗生素仍然是治疗EPEC的主要选择，但鉴于抗生素耐药菌株的快速出现和传播，寻找抗生素的替代品已成为关键研究领域之一。在本研究中，我们探讨了花青素类化合物飞燕草苷（MG）能否通过使用多组学方法，在由鼠疫沙门氏菌诱导的鼠模型中，减轻EPEC相关的表型。MG的补充剂恢复了鼠疫沙门氏菌感染小鼠的体重下降，并改善了结肠隐窝长度及组织病理学评分。